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Peter Thomas Roth Peptide Skinjection Moisture Infusion Refillable Cream

This refillable moisturizer is loaded with peptides designed to plump skin and combat visible signs of aging. Its rich texture delivers intense hydration, making it a good choice for those seeking a more supple and youthful appearance.

Sephora price

$56.00

Price matters most when you are trying to learn whether this lane belongs in your routine without turning the test into a luxury gamble.

Sephora reviews

4.5 / 5

About 543 reviews on the current Sephora source, so there is real volume behind the reputation.

Shoppers keep mentioning

21 Peptides and NeuropeptidesFine Lines and WrinklesDrynessand Loss of Firmness and Elasticity

These are the shopper themes that keep showing up around this listing and shape why people open it in the first place.

Glass take

4.5 / 5 overall fit

A rich, peptide-forward moisturizer that delivers on hydration and targets visible signs of aging.

Peter Thomas Roth Peptide Skinjection Moisture Infusion Refillable Cream

Sephora snapshot refreshed April 23, 2026

Price, rating, review count, and source status come from Sephora. Glass adds the routine fit, overlap risk, and what to compare next.

View Sephora

What Sephora says

What this product is supposed to do

A peptide-packed moisturizer that visibly plumps your skin with intense hydration, restoring a youthful, bouncy look.

NormalDryCombinationand OilyFine Lines and WrinklesDrynessand Loss of Firmness and Elasticity

Apply to your face and neck twice daily.

For external use only.

How to refill:

Squeeze and lift out empty moisturizer pod.

Click in new refill pod.

Peel off the seal and enjoy.

What Glass adds

What actually matters before you buy it

A solid, peptide-rich moisturizer that excels at hydration and targeting common aging concerns. The refillable packaging is a nice touch for sustainability.

Peptide Benefits

Users frequently mention the noticeable improvement in skin texture and the reduction in the appearance of fine lines, attributing these results to the high peptide content.

Hydration and Comfort

Many reviews highlight how effectively this cream hydrates the skin, providing lasting comfort and a smooth feel, especially for drier skin types.

Best for

When this is a smart buy

  • Dry and combination skin
  • Those concerned with fine lines and wrinkles
  • Users seeking intense hydration

Skip if

When this is the wrong lane

  • You have very oily skin and prefer lightweight formulas
  • You are sensitive to rich creams

Routine Fit

How to incorporate this moisturizer

Apply this cream after your serums and treatments, both morning and night. Gently massage it into your face and neck until fully absorbed. The refillable design makes it easy to replace the inner pod once it's empty.

Why it works

Where it earns the slot and where it does not

The useful question is not whether this product is good in a vacuum. It is whether it makes your routine easier to run or just adds one more bottle with a familiar ingredient on it.

What it actually does well

  • High concentration of peptides
  • Deeply hydrating
  • Improves skin plumpness and firmness
  • Refillable packaging

Where it starts to feel redundant

  • May be too rich for very oily skin types
  • Higher price point

Routine fit

Where it belongs in the stack

Morning and Night

This moisturizer is suitable for both morning and evening routines. Use it as the final step to lock in hydration and active ingredients.

Glass rating

How this formula scores in real life

4.5/ 5 overall

A rich, peptide-forward moisturizer that delivers on hydration and targets visible signs of aging.

Hydration

4.6 / 5

This cream provides a substantial boost of moisture, leaving skin feeling plump and comfortable.

Texture

4.4 / 5

The texture is rich and creamy, absorbing well without feeling heavy or greasy.

Anti-aging

4.3 / 5

The blend of peptides appears to help smooth the appearance of fine lines and improve skin's firmness over time.

Full ingredient breakdown

Every ingredient, what it does, and whether I care

Solvent

Water/Aqua/Eau

Badness

0.0 / 10

The base of the formulation, dissolving other ingredients.

Usually helps with

All skin types

Watch for

None

Humectant

Glycerin

Badness

0.0 / 10

Attracts water to the skin, helping to keep it hydrated and supple.

Usually helps with

All skin types

Watch for

None

Emollient/Occlusive

Dimethicone

Badness

1.0 / 10

A silicone that provides a smooth feel and helps to lock in moisture, creating a protective barrier.

Usually helps with

Dry, normal, combination skin

Watch for

Can feel heavy on very oily skin

Emollient

Olive Oil Decylesters

Badness

0.0 / 10

Derived from olive oil, it helps to soften and smooth the skin.

Usually helps with

Dry, normal skin

Watch for

None

Humectant

Glycereth-26

Badness

0.0 / 10

A humectant that helps to attract and retain moisture.

Usually helps with

All skin types

Watch for

None

Emollient

Squalane

Badness

0.0 / 10

A stable, hydrogenated form of squalene, it mimics the skin's natural oils to moisturize and soften.

Usually helps with

All skin types

Watch for

None

Humectant/Solvent

Butylene Glycol

Badness

0.0 / 10

Helps to draw moisture into the skin and improves the texture of the product.

Usually helps with

All skin types

Watch for

None

Emollient/Emulsifier

Behenyl Alcohol

Badness

0.0 / 10

A fatty alcohol that helps to condition and soften the skin, and stabilize the formula.

Usually helps with

All skin types

Watch for

None

Emollient/Film Former

Polysilicone-11

Badness

1.0 / 10

A silicone that provides a smooth feel and can create a breathable film on the skin.

Usually helps with

Normal, dry, combination skin

Watch for

Can feel heavy on very oily skin

Emollient

Batyl Alcohol

Badness

0.0 / 10

A fatty alcohol that helps to condition and soften the skin.

Usually helps with

All skin types

Watch for

None

Emollient

Simmondsia Chinensis (Jojoba) Seed Oil

Badness

0.0 / 10

Mimics the skin's natural sebum, providing excellent moisture and balancing properties.

Usually helps with

All skin types

Watch for

None

Peptide

Hexapeptide-11

Badness

2.0 / 10

A peptide that may help improve skin elasticity and firmness.

Usually helps with

Mature skin, loss of firmness

Watch for

None

Peptide

Dipeptide Diaminobutyroyl Benzylamide Diacetate

Badness

3.0 / 10

Often referred to as a 'Botox-like' peptide, it may help relax facial muscles to reduce the appearance of expression lines.

Usually helps with

Expression lines

Watch for

Results can vary

Peptide

Palmitoyl Tripeptide-5

Badness

2.0 / 10

A peptide that can help stimulate collagen production, improving skin firmness and reducing wrinkles.

Usually helps with

Wrinkles, loss of firmness

Watch for

None

Peptide

Tripeptide-10 Citrulline

Badness

2.0 / 10

A peptide that may help improve skin's hydration and elasticity.

Usually helps with

Dryness, loss of elasticity

Watch for

None

Peptide

Acetyl Hexapeptide-1

Badness

3.0 / 10

A peptide designed to mimic the effects of natural neurotransmitters, potentially reducing the appearance of wrinkles.

Usually helps with

Expression lines

Watch for

None

Peptide

Acetyl Tetrapeptide-11

Badness

2.0 / 10

A peptide that may help improve skin's structure and firmness.

Usually helps with

Loss of firmness

Watch for

None

Peptide

Acetyl Hexapeptide-8

Badness

3.0 / 10

Another 'Botox-like' peptide that aims to reduce the appearance of wrinkles by relaxing facial muscles.

Usually helps with

Expression lines

Watch for

None

Peptide

Palmitoyl Hexapeptide-12

Badness

2.0 / 10

A peptide that may help improve skin's firmness and elasticity.

Usually helps with

Loss of firmness, wrinkles

Watch for

None

Peptide

Acetyl Tetrapeptide-9

Badness

2.0 / 10

A peptide that may help improve skin's texture and firmness.

Usually helps with

Loss of firmness

Watch for

None

Peptide

Palmitoyl Tetrapeptide-7

Badness

2.0 / 10

Works with other peptides to help reduce inflammation and improve skin's appearance.

Usually helps with

Redness, aging skin

Watch for

None

Peptide

Acetyl Tetrapeptide-2

Badness

2.0 / 10

A peptide that may help improve skin's firmness and elasticity.

Usually helps with

Loss of firmness

Watch for

None

Peptide

Acetyl Octapeptide-3

Badness

3.0 / 10

A peptide that targets expression lines by influencing neurotransmitter release.

Usually helps with

Expression lines

Watch for

None

Peptide

Palmitoyl Hexapeptide-19

Badness

2.0 / 10

A peptide that may help reduce the appearance of wrinkles.

Usually helps with

Wrinkles

Watch for

None

Peptide

Trifluoroacetyl Tripeptide-2

Badness

2.0 / 10

A peptide that may help improve skin's firmness and elasticity.

Usually helps with

Loss of firmness

Watch for

None

Peptide

Tripeptide-1

Badness

2.0 / 10

A peptide that may help stimulate collagen production.

Usually helps with

Wrinkles, loss of firmness

Watch for

None

Peptide

Palmitoyl Oligopeptide

Badness

2.0 / 10

A peptide that may help improve skin's firmness and elasticity.

Usually helps with

Loss of firmness, wrinkles

Watch for

None

Peptide

Palmitoyl Tripeptide-1

Badness

2.0 / 10

A peptide that may help stimulate collagen production.

Usually helps with

Wrinkles, loss of firmness

Watch for

None

Humectant

Potassium Hydrolyzed Polygamma-Glutamate

Badness

1.0 / 10

A derivative of polyglutamic acid, it helps to hydrate and moisturize the skin.

Usually helps with

Dry, dehydrated skin

Watch for

None

Humectant

Sodium Polyglutamate

Badness

1.0 / 10

A humectant that can hold more water than hyaluronic acid, providing intense hydration.

Usually helps with

Dry, dehydrated skin

Watch for

None

Emollient

Squalene

Badness

0.0 / 10

A lipid that is naturally found in the skin, it helps to moisturize and soften.

Usually helps with

All skin types

Watch for

None

Colorant/Opacifier

Mica (CI 77019)

Badness

0.0 / 10

A mineral that provides a subtle shimmer and can help to brighten the skin's appearance.

Usually helps with

All skin types

Watch for

None

Humectant

Sodium Hyaluronate

Badness

0.0 / 10

A salt form of hyaluronic acid that attracts and holds moisture, plumping the skin.

Usually helps with

All skin types, dehydrated skin

Watch for

None

Preservative

Sorbic Acid

Badness

1.0 / 10

A mild preservative used to prevent microbial growth.

Usually helps with

All skin types

Watch for

Rarely, can cause irritation

Antioxidant

Tocopherol

Badness

0.0 / 10

A form of Vitamin E that helps protect the skin from environmental damage.

Usually helps with

All skin types

Watch for

None

Botanical Extract

Cereus Grandiflorus (Cactus) Flower Extract

Badness

0.0 / 10

A botanical extract with potential soothing and antioxidant properties.

Usually helps with

All skin types

Watch for

None

Skin-Conditioning Agent

Pseudoalteromonas Ferment Extract

Badness

1.0 / 10

A fermented extract that can help improve skin hydration and barrier function.

Usually helps with

Dry, dehydrated skin

Watch for

None

Preservative Booster/Skin-Conditioning Agent

Leuconostoc/Radish Root Ferment Filtrate

Badness

0.0 / 10

A fermented ingredient that can help condition the skin and act as a preservative.

Usually helps with

All skin types

Watch for

None

Mineral Salt

Magnesium Chloride

Badness

0.0 / 10

A mineral salt that can help condition the skin.

Usually helps with

All skin types

Watch for

None

Preservative

Phenoxyethanol

Badness

2.0 / 10

A common preservative used to prevent bacterial contamination.

Usually helps with

All skin types

Watch for

Can be irritating for some sensitive skin types

Emollient/Emulsifier

Cetyl Alcohol

Badness

0.0 / 10

A fatty alcohol that softens and smooths the skin, and helps to stabilize the formula.

Usually helps with

All skin types

Watch for

None

Emollient/Emulsifier

Stearyl Alcohol

Badness

0.0 / 10

A fatty alcohol that softens and smooths the skin, and helps to stabilize the formula.

Usually helps with

All skin types

Watch for

None

Humectant

Trehalose

Badness

0.0 / 10

A sugar that helps the skin retain moisture and protects it from dryness.

Usually helps with

Dry, dehydrated skin

Watch for

None

Emulsifier/Emollient

Glyceryl Stearate

Badness

0.0 / 10

An emulsifier that helps mix oil and water, and also softens the skin.

Usually helps with

All skin types

Watch for

None

Humectant

Silanetriol Trehalose Ether

Badness

1.0 / 10

A derivative of trehalose that helps to hydrate and condition the skin.

Usually helps with

Dry, dehydrated skin

Watch for

None

Humectant

Mannitol

Badness

0.0 / 10

A sugar alcohol that attracts and retains moisture.

Usually helps with

All skin types

Watch for

None

Emollient/Skin-Conditioning Agent

Phytosterols

Badness

1.0 / 10

Plant-derived sterols that help to condition and soothe the skin.

Usually helps with

All skin types

Watch for

None

Thickener

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Badness

1.0 / 10

A polymer used to thicken the product and improve its texture.

Usually helps with

All skin types

Watch for

None

Emollient

Caprylic/Capric Triglyceride

Badness

0.0 / 10

A derivative of coconut oil and glycerin, it's a light emollient that helps to replenish the skin.

Usually helps with

All skin types

Watch for

None

Emulsifier/Emollient

Hydrogenated Lecithin

Badness

0.0 / 10

A modified form of lecithin that helps to emulsify and condition the skin.

Usually helps with

All skin types

Watch for

None

Emulsifier

Polyglyceryl-10 Myristate

Badness

0.0 / 10

An emulsifier derived from glycerin and myristic acid, used to blend oil and water.

Usually helps with

All skin types

Watch for

None

Emulsifier

Polysorbate 20

Badness

1.0 / 10

An emulsifier used to help disperse oils in water-based formulas.

Usually helps with

All skin types

Watch for

Can be a skin irritant for some

Solvent/Penetration Enhancer

Dimethyl Isosorbide

Badness

1.0 / 10

Helps to dissolve ingredients and improve their penetration into the skin.

Usually helps with

All skin types

Watch for

None

Preservative

Sodium Benzoate

Badness

1.0 / 10

A common preservative that helps prevent microbial growth.

Usually helps with

All skin types

Watch for

Can cause irritation in sensitive individuals, especially when combined with ascorbic acid

Preservative

Potassium Sorbate

Badness

1.0 / 10

A salt of sorbic acid used as a preservative.

Usually helps with

All skin types

Watch for

Can cause irritation in sensitive individuals

Humectant/Preservative Booster

Caprylyl Glycol

Badness

0.0 / 10

A skin-conditioning agent that also helps to preserve the product.

Usually helps with

All skin types

Watch for

None

pH Adjuster

Sodium Hydroxide

Badness

0.0 / 10

Used to adjust the pH of the product to ensure stability and efficacy.

Usually helps with

All skin types

Watch for

None in this concentration

Emulsifier

Laureth-12

Badness

1.0 / 10

An emulsifier that helps to blend oil and water components.

Usually helps with

All skin types

Watch for

None

Skin-Conditioning Agent

Hydrolyzed Wheat Protein

Badness

1.0 / 10

A protein derived from wheat that can help moisturize and condition the skin.

Usually helps with

Dry skin

Watch for

Avoid if you have a gluten sensitivity or celiac disease

Emulsifier/Skin-Conditioning Agent

Lecithin

Badness

0.0 / 10

A phospholipid that helps to emulsify ingredients and condition the skin.

Usually helps with

All skin types

Watch for

None

pH Adjuster

Disodium Phosphate

Badness

0.0 / 10

Used to adjust the pH of the product.

Usually helps with

All skin types

Watch for

None

Skin-Conditioning Agent

Hydrolyzed Soy Protein

Badness

1.0 / 10

A protein derived from soy that can help moisturize and condition the skin.

Usually helps with

All skin types

Watch for

None

Thickener

Carbomer

Badness

1.0 / 10

A polymer used to thicken the product and create a gel-like consistency.

Usually helps with

All skin types

Watch for

None

Humectant

Dextran

Badness

0.0 / 10

A polysaccharide that can help attract and retain moisture.

Usually helps with

All skin types

Watch for

None

Humectant/Preservative Booster

Ethylhexylglycerin

Badness

0.0 / 10

A skin-conditioning agent that also enhances the effectiveness of preservatives.

Usually helps with

All skin types

Watch for

None

Humectant

Sodium Lactate

Badness

0.0 / 10

A salt of lactic acid that helps to hydrate and condition the skin.

Usually helps with

All skin types

Watch for

None

Peptide

Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate

Badness

3.0 / 10

A complex peptide that may help improve skin firmness and reduce the appearance of wrinkles.

Usually helps with

Loss of firmness, wrinkles

Watch for

None

pH Adjuster

Sodium Phosphate

Badness

0.0 / 10

Used to adjust the pH of the product.

Usually helps with

All skin types

Watch for

None

Thickener/Emulsifier

Xanthan Gum

Badness

0.0 / 10

A polysaccharide used to thicken the product and stabilize emulsions.

Usually helps with

All skin types

Watch for

None

pH Adjuster

Triethanolamine

Badness

2.0 / 10

Used to adjust the pH of the product. Can be irritating in higher concentrations.

Usually helps with

All skin types

Watch for

Potential for irritation if formulation pH is not well-controlled

Thickener

Acrylates Copolymer

Badness

1.0 / 10

A polymer used to thicken the product and improve its texture.

Usually helps with

All skin types

Watch for

None

Compare before you buy

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FAQ

The fast answers people actually need

Is this moisturizer good for anti-aging?

Yes, with its extensive peptide complex, this moisturizer is designed to target fine lines, wrinkles, and improve skin firmness.

What skin types is this best for?

It is particularly beneficial for normal, dry, and combination skin types due to its rich, hydrating formula. Those with very oily skin might find it too heavy.

How does the refillable system work?

You simply squeeze and lift out the empty inner pod and click in a new refill pod. Then, peel off the seal and continue using.

Peter Thomas Roth Peptide Skinjection Moisture Infusion Refillable Cream Review and Routine Fit | Glass